Innovation & Social Impact

"A diverse scientific community broadens scientific innovation." - Rose De Guzman, PhD

Problem: It is unclear how spatial information from place cells in the brain may reciprocally organize subcortical theta-rhythmic activity.

At the University of California, Los Angeles, Rose De Guzman designed a novel chronically implantable Microdrive “OvalDrive36” for in vivo electrophysiology experiments.

OvalDrive36 enabled the discovery of a novel class of neurons: phaser cells.

Problem: Despite the sex difference in mood disorder prevalance, pre-clinical studies that have led to anxiolytic drug discoveries have primarily focused on the male brain and behavior.

At the State University New York - Albany, Rose De Guzman's work has implications for sex-specific therapeutics, especially for women during pregnancy and postpartum.

Problem: Pregnant and postpartum individuals were excluded from initial COVID-19 vaccine trials; thus, data to guide vaccine decision-making are lacking.

At Massachusetts General Hospital - Harvard Medical School, Rose De Guzman's work has implications to help identify vulnerable neonates in the setting of maternal environmental or infectious exposures.

Problem: There is a lack of diversity in the scientific community as compared to the population of the United States, with groups that do make it into the system being paid less, promoted less often, and disproportionately leaving STEM careers.

At MGH-HMS, Rose De Guzman founded the “Pathways to Science and Medicine” initiative in which Bunker Hill Community College students are paired with Harvard-affiliated STEMM leaders in a career exploration mentorship program. PSM achieved such an impact that the MGH Center for Diversity and Inclusion adopted the program.

Problem: Stigma stands in the way of people seeking help, causing mood disorders to go undiagnosed and untreated.

As a Board Member at Families for Depression Awareness, Rose De Guzman combines neuroscience research and mental health advocacy to bring in expert advice and provide evidence-based resources to families.